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Nanofibres in Drug Delivery

Gareth R. Williams, Bahijja T. Raimi-Abraham, and C. J. Luo

ISBN: 9781787350182

Publication: September 17, 2018

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What is this?

In recent years there has been an explosion of interest in the production of nanoscale fibres for drug delivery and tissue engineering. Nanofibres in Drug Delivery aims to outline to new researchers in the field the utility of nanofibres in drug delivery, and to explain to them how to prepare fibres in the laboratory.

The book begins with a brief discussion of the main concepts in pharmaceutical science. The authors then introduce the key techniques that can be used for fibre production and explain briefly the theory behind them. They discuss the experimental implementation of fibre production, starting with the simplest possible set-up and then moving on to consider more complex arrangements. As they do so, they offer advice from their own experience of fibre production, and use examples from current literature to show how each particular type of fibre can be applied to drug delivery. They also consider how fibre production could be moved beyond the research laboratory into industry, discussing regulatory and scale-up aspects.

Gareth R. Williams graduated with a DPhil from the University of Oxford in 2005, and joined the UCL School of Pharmacy in 2012. His research group work on a range of topics in drug delivery and vaccine formulation, with a particular emphasis on the use of electrohydrodynamic approaches to develop solid dispersions. He was awarded Fellowship of the Royal Society of Chemistry in 2017.

C. J. Luo graduated from UCL in 2012 with a PhD in Biomedical Engineering. She took up a postdoctoral position at the University of Cambridge in 2013 before returning to UCL in 2016. Her current research is funded by the Engineering and Physical Sciences Research Council.Bahijja T. Raimi-Abraham graduated with a PhD in 2012 from the University of East Anglia School of Pharmacy in 2012 and is a registered and practising pharmacist. She went on to undertake postdoctoral research funded by the Engineering and Physical Sciences Research Council at the UCL School of Pharmacy, before joining King’s College London as a lecturer in 2017.

1 Introduction

1.1 Preamble

1.2 Nanofibres

1.3 Key concepts in drug delivery

1.4 Nanofibre characterisation

1.5 An overview of contemporary pharmaceutical technology

1.6 Summary

1.7 References

1.8 Bibliography

2 Electrospinning fundamentals

2.1 Background

2.2 A brief history of electrospinning

2.3 EHD fundamentals

2.4 Understanding the electrospinning process

2.5 The parameters affecting electrospinning

2.6 The experimental set- up

2.7 Fibre properties

2.8 Characterisation

2.9 Summary

2.10 References

3 Monoaxial electrospinning

3.1 Introduction

3.2 Experimental considerations

3.3 Fibre properties

3.4 Some typical results

3.5 Fast- dissolving drug delivery systems

3.6 Extended- release systems

3.7 pH- controlled delivery

3.8 Pulsatile release

3.9 Multilayer materials

3.10 Thermoresponsive systems

3.11 Emulsion and suspension electrospinning

3.12 Tissue- engineering applications

3.13 Using fibres as sacrificial templates

3.14 Conclusions

3.15 References

4 Coaxial and multi- axial electrospinning

4.1 Introduction

4.2 Experimental considerations

4.3 Extended- release systems

4.4 Targeted drug delivery

4.5 Multifunctional materials

4.6 Other applications

4.7 Protein delivery systems

4.8 Cell electrospinning

4.9 Modified coaxial spinning

4.10 Triaxial and quad- axial systems

4.11 Conclusions

4.12 References

5 Side- by- side electrospinning

5.1 Introduction

5.2 Experimental considerations

5.3 Janus fibres in drug delivery

5.4 Conclusions

5.5 References

6 Alternative nanofibre fabrication approaches

6.1 Introduction

6.2 Alternating current (AC) electrospinning

6.3 Melt electrospinning

6.4 Centrifugal spinning

6.5 Solution blowing and melt blowing

6.6 Electroblowing

6.7 Pressurised gyration

6.8 Electrospraying

6.9 Microfluidic spinning

6.10 Fibre production on the move

6.11 Other techniques

6.12 Conclusions

6.13 References

7 Moving from the bench to the clinic

7.1 Introduction

7.2 Scale- up

7.3 Regulatory requirements and GMP manufacturing

7.4 Conclusions

7.5 References

8 Conclusions and outlook

Format: Open Access PDF

ISBN: 9781787350182

Publication: September 17, 2018

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